BDBM50060632 (S)-2-Amino-3-(5-chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid::(S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid::CHEMBL121388

SMILES N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(O)=O

InChI Key InChIKey=HEHLSRRDKJVHOM-UHFFFAOYSA-N

Data  10 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50060632   

TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataEC50:  2.11E+3nMAssay Description:Agonist activity at cyclothiazide-desensitized rat recombinant flip iGluR2(Q) expressed in Xenopus laevis oocytes by two electrode voltage-clamp elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  37nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  45nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 1(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  451nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  451nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 4(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  561nMAssay Description:Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Rat)
European Research Centre For Drug Discovery and Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed