BDBM50060601 (E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H,3H)-dione::(S)-Pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide::6-((E)-3-Oxo-3-phenyl-propenyl)-1H-pyrimidine-2,4-dione::CHEMBL317488::L-pro-L-leu-gly-NH2::L-prolyl-L-leucylglycinamide::Pyrrolidine-2-carboxylic acid [1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide

SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)NCC(N)=O

InChI Key InChIKey=NOOJLZTTWSNHOX-UHFFFAOYSA-N

Data  15 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50060601   

TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulation of human D2 receptor expressed in CHO cells assessed as inhibition of forskolin stimulated cAMP accumulation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant of compound in presence of Gpp(NH)p (Pre treated with 1 uM) calculated for the high affinity components of the [3H]spiroperidol b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitory constant of compound in absence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory constant of compound in presence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  0.130nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  60nMAssay Description:Inhibitory constant of compound in absence of Gpp(NH)p (Pre treated with 1 uM) calculated for the high affinity components of the [3H]spiroperidol bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  60nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  60nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  60nMAssay Description:Inhibitory constant of compound in presence of Gpp(NH)p calculated for the low affinity components of the [3H]spiroperidol binding to Dopamine recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  60.1nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of Gp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  73nMAssay Description:Inhibitory constant of compound in absence of Gpp(NH)p calculated for the low affinity components of the [3H]spiroperidol binding to Dopamine recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Porto

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  73.2nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of Gp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601(L-pro-L-leu-gly-NH2 | L-prolyl-L-leucylglycinamide...)
Affinity DataKi:  78nMAssay Description:Percentage of receptor in the high affinity form for the compound to Dopamine receptor D2 in absence of Gpp(NH)p (pre treated with 1 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed