BDBM50058844 CHEMBL3325741::US9290476, 1

SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Cc3ccccc3)c(Cl)c2c1

InChI Key InChIKey=IGBFRJGBHUMYIT-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50058844   

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50058844(CHEMBL3325741 | US9290476, 1)
Affinity DataKd:  18nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50058844(CHEMBL3325741 | US9290476, 1)
Affinity DataKd:  18nMAssay Description:Binding affinity to human wild type RORgammat ligand binding domain expressed in Escherichia coli by thermofluor assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50058844(CHEMBL3325741 | US9290476, 1)
Affinity DataIC50: 350nMAssay Description:Modulator activity at GAL4-tagged human RORgammat ligand binding domain expressed HEK293T cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed