BDBM50057518 4-(5-Phenyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonamide::4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide::CHEMBL29920

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccccc1)C(F)(F)F

InChI Key InChIKey=MQPLMBSDWYIIID-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50057518   

TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 5.51E+4nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 2.13E+5nMAssay Description:Inhibition of purified ovine COX-1 by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 32nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 32.4nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 31.6nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Keio University

Curated by ChEMBL
LigandPNGBDBM50057518(4-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)be...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed