BDBM50056764 CHEMBL355423::N'-Hydroxy-N'-methyl-N-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3indolyl)methyl]urea

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CNC(=O)N(C)O)c2c1

InChI Key InChIKey=SJAYKBDANOQLLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50056764   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056764(N'-Hydroxy-N'-methyl-N-[1-(4-chlorobenzoyl)-5-meth...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056764(N'-Hydroxy-N'-methyl-N-[1-(4-chlorobenzoyl)-5-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed