BDBM50054727 1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperazine::CHEMBL102119

SMILES Fc1ccc(cc1)C(OCCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=NNPGQYMXSXYOPB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50054727   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054727(1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 1.10nMAssay Description:Compound was tested for binding against Dopamine transporter using radioligand as [3H]-RTI 55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054727(1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 7.30nMAssay Description:Binding against Dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054727(1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054727(1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054727(1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 278nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed