BDBM50054722 (2S,5R)-1,4-Bis-(2-benzhydryloxy-ethyl)-2,5-dimethyl-piperazine::CHEMBL342120

SMILES C[C@H]1CN(CCOC(c2ccccc2)c2ccccc2)[C@H](C)CN1CCOC(c1ccccc1)c1ccccc1

InChI Key InChIKey=LIDYDSLIYWWVDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50054722   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054722((2S,5R)-1,4-Bis-(2-benzhydryloxy-ethyl)-2,5-dimeth...)
Affinity DataIC50: 33nMAssay Description:Binding affinity against dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054722((2S,5R)-1,4-Bis-(2-benzhydryloxy-ethyl)-2,5-dimeth...)
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054722((2S,5R)-1,4-Bis-(2-benzhydryloxy-ethyl)-2,5-dimeth...)
Affinity DataIC50: 35nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054722((2S,5R)-1,4-Bis-(2-benzhydryloxy-ethyl)-2,5-dimeth...)
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed