BDBM50054720 (2S,5R)-1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-2,5-dimethyl-piperazine::CHEMBL142337

SMILES C[C@H]1CN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)[C@H](C)CN1CCOC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=CBIYBJFMBUATEB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50054720   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054720((2S,5R)-1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]...)
Affinity DataIC50: 86nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054720((2S,5R)-1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]...)
Affinity DataIC50: 3.64E+3nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054720((2S,5R)-1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]...)
Affinity DataIC50: 4.24E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50054720((2S,5R)-1,4-Bis-{2-[bis-(4-fluoro-phenyl)-methoxy]...)
Affinity DataIC50: 36nMAssay Description:Binding affinity against dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed