BDBM50054654 CHEMBL4068839

SMILES Nc1ncnc2n(nc(-c3ccc(OCc4ccccn4)c(Cl)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=RVCKMZIQUFKZFD-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50054654   

TargetEpidermal growth factor receptor(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of full-length recombinant human His-tagged BLK expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 111nMAssay Description:Inhibition of full-length recombinant human His-tagged BMX expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant human IgG1 Fc-tagged ERBB2 cytoplasmic domain (676 to 1255 residues) expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 161nMAssay Description:Inhibition of full-length recombinant human His-tagged MEK1 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataEC50:  70nMAssay Description:Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)
Affinity DataIC50: 25nMAssay Description:Inhibition of full-length recombinant human His-tagged BTK cytoplasmic domain expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2020
Entry Details Article
PubMed