BDBM50052046 5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one::CHEMBL329653

SMILES CCC1(Oc2ccccc2-n2cccc2C1=O)c1ccccc1

InChI Key InChIKey=NDEBJOYSLDGPCZ-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50052046   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataIC50: 250nMAssay Description:Compound was tested for Inhibition of HIV-1 RT activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Universita` Di Siena

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human adenosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi:  190nMAssay Description:In vitro inhibitory activity against HIV-1 wild type reverse transcriptase (RT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi:  750nMAssay Description:In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution L100IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi:  3.90E+3nMAssay Description:In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution V106AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi:  7.70E+3nMAssay Description:In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution K103NMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y188LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Universitá

Curated by ChEMBL
LigandPNGBDBM50052046(5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-on...)
Affinity DataKi: >1.00E+4nMAssay Description:In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y181IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed