BDBM50051404 CHEMBL312541::[14-Cyclopentyl-11-cyclopropyl-8-(2-methyl-1H-indol-3-ylmethyl)-4,7,10,13,16-pentaoxo-hexadecahydro-3a,6,9,12,15-pentaaza-cyclopentacyclopentadecen-5-yl]-acetic acid

SMILES Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NC1=O)C1CCCC1)C1CC1

InChI Key InChIKey=DURQGRPWKJTJCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50051404   

TargetEndothelin-1 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051404([14-Cyclopentyl-11-cyclopropyl-8-(2-methyl-1H-indo...)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051404([14-Cyclopentyl-11-cyclopropyl-8-(2-methyl-1H-indo...)
Affinity DataIC50: 130nMAssay Description:Binding affinity towards Endothelin B receptor in human girardi heart cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051404([14-Cyclopentyl-11-cyclopropyl-8-(2-methyl-1H-indo...)
Affinity DataIC50: 59nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Pig)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051404([14-Cyclopentyl-11-cyclopropyl-8-(2-methyl-1H-indo...)
Affinity DataIC50: 1.80nMAssay Description:Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed