BDBM50049365 1-Benzyl-4-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine::1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)piperidine::CHEMBL34032

SMILES Fc1ccc(cc1)C(OCCC1CCN(Cc2ccccc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=LEJRLSZVESQKJK-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50049365   

LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataIC50: 198nMAssay Description:Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]citalopram displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataIC50: 9.70nMAssay Description:Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]CFT displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataIC50: 198nMAssay Description:IC50 value was evaluated using [3H]citalopram (radioligand) on serotonin transporter in rat striatum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataIC50: 35nMAssay Description:Affinity was evaluated using [3H]WIN-35428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataIC50: 9.70nMAssay Description:IC50 value was evaluated using [3H]WIN-35428 (radioligand) on Dopamine transporter in rat striatum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataKi:  9.90nMAssay Description:Affinity at rat dopamine transporter using [125I]RTI-55 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataKi:  171nMAssay Description:Affinity at rat serotonin transporter using [125I]RTI-55 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50049365(1-benzyl-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)pi...)
Affinity DataKi:  171nMAssay Description:Displacement of [125I]RTI55 from SERT in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed