BDBM50049039 2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-spiro[4.4]non-2-ene::CHEMBL327900

SMILES CS(=O)(=O)c1ccc(cc1)C1=C(CC2(CCCC2)C1)c1ccc(F)cc1

InChI Key InChIKey=PMQKCWAUARTKGJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50049039   

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory activity against constitutive form of human recombinant Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 62nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 62nMAssay Description:In vitro inhibitory activity against inducible form of human recombinant Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 61.7nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed