BDBM50044849 CHEMBL3311308

SMILES COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C

InChI Key InChIKey=FQUAFMNPXPXOJE-UHFFFAOYSA-N

Data  45 IC50  52 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 97 hits for monomerid = 50044849   

TargetGastric inhibitory polypeptide receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity at human GIP receptor expressed in HEK293 cells by IP4 HTRF EFC cAMP/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 2(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against rat GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 2(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against mouse GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled estrogen receptor 1(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against rat GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 3(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against mouse GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against human GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against human GPR40 expressed in U2OS cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetG-protein coupled receptor 39(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity against human GPR39 expressed in CHO cells by BacMam IP1 HTRF/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity at human glucagon receptor expressed in CHO-K1 cells by LANCE HTRF/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucagon receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human glucagon receptor expressed in CHO cells by luciferase HTS/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human Kv1.5 expressed in CHO cells by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human endothelin B receptor expressed in CHO cells by luminescence HTS/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR(Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human OPRM1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human OPRM1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human OPRK1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human OPRK1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NET by BacMam bind SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DAT by BacMam Binding SPA/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 3(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at mouse FFA3 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human 5-HT2C receptor expressed in CHO cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 4(Human)
University of Southern Denmark

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50:  490nMAssay Description:Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interacti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Blocking of human TRPM5 expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetShort transient receptor potential channel 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Blocking of human TRPC3 expressed in HEK cells by MSRII FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTaste receptor type 2 member 16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human TAS2R16 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTaste receptor type 2 member 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human TAS2R14 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of mouse SGLT3b expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of human SGLT1 expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 15 member 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human PePT1 receptor expressed in HEK cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human histamine H1 receptor by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.98E+4nMAssay Description:Antagonist activity at human adrenergic alpha1B receptor assessed as intracellular calcium by summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 2(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at mouse FFA2 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <3.98E+4nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in CHO cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <3.98E+4nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in HEK cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVasopressin V1a receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity at human vasopressin V1a receptor by double wash FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Induction of human TRPM5 opening expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetShort transient receptor potential channel 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Induction of human TRPC3 opening expressed in HEK cells by MSRII FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTaste receptor type 2 member 60(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R60 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTaste receptor type 2 member 41(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R41 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTaste receptor type 2 member 16(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R16 expressed in U2OS cells by summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRelaxin-3 receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human GPR100 expressed in U2OS cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 15 member 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human PePT1 receptor expressed in HEK cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity at human NK1 receptor by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044849(CHEMBL3311308)
Affinity DataIC50: 3.16E+4nMAssay Description:Antagonist activity at human beta 2 adrenergic receptor by TR FRET/summary (Abse5) assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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