BDBM50040979 CHEMBL3354966::US11214548, Compound 408

SMILES [H][C@@]12C[C@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NCC1CCOCC1

InChI Key InChIKey=BIMFLDLUJSAALT-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040979   

TargetCannabinoid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50:  76nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50:  67nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50:  2.69E+4nMAssay Description:Table B: HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040979(CHEMBL3354966 | US11214548, Compound 408)
Affinity DataEC50:  75.8nMAssay Description:Table D: Radioligand binding assays for human CB2 receptors were performed using two different agonist radioligands, [3H]CP55,940 and [3H]WIN55,212-2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent