BDBM50040805 CHEMBL3361255

SMILES NC(=O)[C@@H](O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@@H](CC4)N4CCOCC4)c3c12

InChI Key InChIKey=ZSMULWAVKYFPSS-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50040805   

TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataKi:  1nMAssay Description:Inhibition of N-terminal GST-fused full-length human IRAK4 (1 to 460 amino acids) assessed as reduction in phosphorylated substrates by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed