BDBM50040733 CHEMBL3353215::US10064861, Compound 20

SMILES Oc1ccc-2cc1Cn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12

InChI Key InChIKey=GFCOIRMJYSQJJE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50040733   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040733(CHEMBL3353215 | US10064861, Compound 20)
Affinity DataIC50: 100nMAssay Description:Inhibition of IRAK4 (unknown origin) by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040733(CHEMBL3353215 | US10064861, Compound 20)
Affinity DataIC50: 100nMAssay Description:Inhibition of IRAK1 (unknown origin) by radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040733(CHEMBL3353215 | US10064861, Compound 20)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040733(CHEMBL3353215 | US10064861, Compound 20)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent