BDBM50040727 CHEMBL3353220::US9255110, 7

SMILES COc1cc2ncccc2cc1NC(=O)c1csc2cnc(nc12)N(C)CCN

InChI Key InChIKey=BUJSZRICYLPWCM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040727   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 8nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 983nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 410nMpH: 7.2 T: 2°CAssay Description:SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 410nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 983nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50040727(US9255110, 7 | CHEMBL3353220)
Affinity DataIC50: 8nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed