BDBM50040193 1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine::CHEMBL18618

SMILES C1CCN(C1)C1(CCCCC1)c1cc2ccccc2s1

InChI Key InChIKey=NDVZYCXZMVQYBS-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50040193   

TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataIC50: 6.70nMAssay Description:Displacement of [3H]BTCP (1-[1-(2-benxo[b]thienyl)cyclohexyl]piperidine) from rat forebrain dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataIC50: 78nMAssay Description:Tested for inhibition of radioligand [3H]dopamine (DA) uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataIC50: 684nMAssay Description:Tested for radioligand [3H]cocaine displacement from dopamine transporter in rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]cocaine binding to rat forebrain dopamine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataIC50: 78nMAssay Description:Tested for inhibition of radioligand [3H]dopamine (DA) uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50040193(1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-pyrrolidine...)
Affinity DataKi:  168nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma receptor of guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed