BDBM50038199 5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic acid::5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid::5-(N-2',5'-dihydroxybenzyl)aminosalicylic acid::CHEMBL319620::Lavendustin C

SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O

InChI Key InChIKey=LULATDWLDJOKCX-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50038199   

TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 30nMAssay Description:Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 150nMAssay Description:Inhibition of EGFR(epidermal growth factor receptor) autophosphorylation in ER22 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of EGF-stimulated DNA synthesis in ER22 cells, by measuring [3H]Me-dT incorporation into ER 22 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of EGF-R Tyrosine kinase (TK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p56lck autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CaM-KKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of protein-tyrosine kinase p56lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of EGF-dependent DNA synthesis in ER 22 cells incubated with [3H]TdRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [gamma-32P]-ATP from Epidermal growth factor receptor in A431 cell-free extractsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetNADPH oxidase 4(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50038199(5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid...)
Affinity DataIC50: 43.6nMAssay Description:Inhibition of mouse EGFR by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed