BDBM50036738 (R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-hydroxy-butyl]-piperidin-4-ol::CHEMBL129159

SMILES O[C@H](CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1

InChI Key InChIKey=WNZBBTJFOIOEMP-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50036738   

TargetSigma non-opioid intracellular receptor 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  1.80nMAssay Description:Tested for [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes after 150 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  256nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  279nMAssay Description:Displacement of [3H]spiperone from CHO-K1 cell membranes expressing human dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine 3 receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed