BDBM50036487 5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-quinazoline-2,4-diamine::CHEMBL162270

SMILES COc1cc(cc(OC)c1OC)N(C)Cc1cccc2nc(N)nc(N)c12

InChI Key InChIKey=RJJKDQLFIKMANF-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50036487   

TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036487(5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036487(5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036487(5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036487(5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)
Affinity DataKi:  49nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036487(5-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...)
Affinity DataKi: >500nMAssay Description:Inhibitory compound against Wild-type human DHFR.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed