BDBM50033685 CHEMBL8290::Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

SMILES OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C([O-])=O

InChI Key InChIKey=HZZVJAQRINQKSD-UHFFFAOYSA-M

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50033685   

TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 2.00E+4nMAssay Description:The concentration of compound to inhibit beta-lactamase was measured on Enterobacter cloacae P99More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase TEM(Escherichia coli)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 60nMAssay Description:The concentration of compound to inhibit beta-lactamase was measured on Escherichia coli WC3310More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 2.00E+4nMAssay Description:The concentration of compound to inhibit beta-lactamase was measured on Enterobacter cloacae SC 12368More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 5.39E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50033685(Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-ox...)
Affinity DataIC50: 3.30E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed