BDBM50033447 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-tolyl-piperazin-1-yl)-ethanone::CHEMBL120055::CHEMBL321818

SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1

InChI Key InChIKey=DWSOZYFSYVOVOC-UHFFFAOYSA-N

Data  9 KI  9 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50033447   

LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards muscarinic (M) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataEC50:  0.600nMAssay Description:Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSerotonin 2 (5-HT2) receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataEC50:  110nMAssay Description:Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataEC50:  2.10nMAssay Description:The compound was evaluated for intrinsic activity against human cloned 5-hydroxytryptamine 1B receptor; full agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetAdenosine receptor A2b(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 2C(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxy tryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 3A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards dopaminergic (D2) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetHistamine H1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its affinity towards histaminergic (H 1) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  0.800nMAssay Description:Affinity for 5-hydroxytryptamine 1B receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  0.870nMAssay Description:Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  2nMAssay Description:Affinity for 5-hydroxytryptamine 1D receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity towards cloned human 5-hydroxy tryptamine 1A (5-HT1A) receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  8nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(CHEMBL321818 | CHEMBL120055 | 2-[3-(2-Amino-ethyl)...)
Affinity DataKi:  8nMAssay Description:Affinity for 5-hydroxytryptamine 1A receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article