BDBM50032874 CHEMBL3355683

SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)c1nc(c(Cl)[nH]1)-c1ccc2c(N)n[nH]c2c1

InChI Key InChIKey=LHBYFFXOUVRTCW-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50032874   

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis at 37 degC by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  5nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  23nMAssay Description:Inhibition of human coagulation trypsin using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  4.22E+3nMAssay Description:Inhibition of human coagulation factor 7a using H-(D)-Ile-Pro-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  6.39E+3nMAssay Description:Inhibition of human coagulation factor 10a using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  9.22E+3nMAssay Description:Inhibition of human coagulation factor 12a using H-(D)-CHT-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor X(Rabbit)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of rabbit coagulation factor 10a using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor VII(Rabbit)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of rabbit coagulation factor 7a using H-(D)-Ile-Pro-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi: >1.26E+4nMAssay Description:Inhibition of human coagulation thrombin using pyro-Glu-Pro-Argp-NA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi: >3.49E+4nMAssay Description:Inhibition of human coagulation factor 9a by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed