BDBM50032379 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide::(1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid diethylamide::CHEMBL99946::LEVOMILNACIPRAN

SMILES CCN(CC)C(=O)[C@]1(C[C@H]1CN)c1ccccc1

InChI Key InChIKey=GJJFMKBJSRMPLA-UHFFFAOYSA-N

Data  2 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50032379   

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 30nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of radiolabeled noradrenaline uptake from rat brain NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 320nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of [3H]-paroxetine binding on serotonin transporter of rat cerebral cortical synaptic membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxy...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of Serotonin transporter in cerebral cortical synaptic membrane of rats using [3H]paroxetineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed