BDBM50031872 6-((2,5-dimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52947

SMILES COc1ccc(OC)c(NCc2ccc3nc(N)nc(N)c3n2)c1

InChI Key InChIKey=PIKOPKOXFNIUMO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50031872   

TargetDihydrofolate reductase(Pneumocystis carinii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Concentration inhibiting Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 100nMAssay Description:Concentration inhibiting Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 430nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Baker's yeast)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 280nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 280nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute

Curated by ChEMBL
LigandPNGBDBM50031872(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of rat liver DHFR assessed as reduction in consumption of NADPH using DHFA as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed