BDBM50031795 (N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYLALANYL)METHYL AMINE::(R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide::(R)-N4-hydroxy-2-isobutyl-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide::CHEMBL11306::METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID

SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO

InChI Key InChIKey=MOPRTFSMCQNUCT-UHFFFAOYSA-N

Data  11 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50031795   

TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 0.0460nMAssay Description:Inhibition of human recombinant MMP8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrilysin(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant MMP7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Cathepsin L from human kidneyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested for inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells ( a human B-cell line); value ranges from 1000...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi: <1nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails Article

TargetMatrix metalloproteinase-9(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  2nMAssay Description:Inhibitory concentration of compound against human fibroblast stromelysin (HFS) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeutrophil collagenase(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  2nMAssay Description:Inhibition of human neutrophil collagenase (HNC), MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  6nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article

TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  7nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article

TargetInterstitial collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  7nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  79nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)More data for this Ligand-Target Pair
In DepthDetails Article

TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  79nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  79nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50031795((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)
Affinity DataKi:  89nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails Article