BDBM50030719 4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-2-[5-(propionylamino)-2-(trifluoromethyl)phenyl]-3H-1,2,4-trizol-3-one::CHEMBL276674::N-{3-[3-Butyl-5-oxo-4-(2'-(N-t-butyloxycarbonyl)-Sulfanamido-biphenyl-4-ylmethyl)-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-propionamide::N-{3-[3-Butyl-5-oxo-4-(2'-(tert-butyloxycarbonyl)sulfamoyl-biphenyl-4-ylmethyl)-4,5-dihydro-[1,2,4]triazol-1-yl]-4-trifluoromethyl-phenyl}-propionamide

SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C

InChI Key InChIKey=HQYHXZJKRHOYFK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50030719   

TargetType-2 angiotensin II receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 1nMAssay Description:In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetType-2 angiotensin II receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against AT2 receptor from rat adrenal tissues.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at AT1 receptor in rabbit aorta membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article

TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetType-1 angiotensin II receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50030719(4-[[2'-[N-(tert-Butoxycarbonyl)sulfamoyl]biphenyl-...)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article