BDBM50030476 CHEMBL458603

SMILES Clc1ccc(cc1)-c1nc2sccn2c1\C=N\OCc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=ZQWBOKJVVYNKTL-UHFFFAOYSA-N

Data  11 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50030476   

TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human CAR expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  510nMAssay Description:Agonist activity at human CAR3 expressed in African green monkey COS-1 cells cotransfected with RXRalpha after 24 hrs by CYP2B6-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  20nMAssay Description:Agonist activity at CAR LBD (108 to 348 residues) expressed in human HepG2 cells assessed as receptor binding to PGC1alpha by lanthascreenTR-FRET coa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  570nMAssay Description:Agonist activity at human constitutive androstane receptor expressed in HepG2 cells co-expressing CYP2B6 incubated for 23 hrs by One-Glo luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  990nMAssay Description:Agonist activity at human PXR transfected in human HepG2 cells cotransfected with CYP3A4 incubated for 23 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  620nMAssay Description:Agonist activity at human CAR transfected in human HepG2 cells cotransfected with CYP2B6 incubated for 23 hrs by luciferase reported gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  49nMAssay Description:Agonist activity at Polyhistidine-tagged human CAR LBD expressed in Escherichia coli by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  49nMAssay Description:Agonist activity at Polyhistidine-tagged human CAR LBD expressed in Escherichia coli by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human recombinant GST-tagged CAR LBD incubated for 1 to 4 hrs in presence of fluorescein-labeled PGC1alpha by lanthascreen TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  690nMAssay Description:Agonist activity at human CAR LBD in human HepG2 cells incubated for 24 hrs by firefly luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed