BDBM50028979 8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::CHEMBL266723

SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(C)c2ccccc12

InChI Key InChIKey=XQIPQCHREHNRDI-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50028979   

LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataIC50: 12nMAssay Description:Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataIC50: 3.24E+4nMAssay Description:Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nucleiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataKi:  40nMAssay Description:Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataKi:  74nMAssay Description:Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataKi:  120nMAssay Description:Affinity was evaluated as inhibition constant for dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataKi:  140nMAssay Description:Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028979(8-Chloro-5-methyl-11-(4-methyl-piperazin-1-yl)-5H-...)
Affinity DataKi:  1.10E+3nMAssay Description:Affinity was evaluated as inhibition constant for dopamine D-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed