BDBM50028600 1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-piperazine::CHEMBL90882

SMILES CN1CCN(CC1)C1=Cc2ccccc2Oc2ccc(Cl)cc12

InChI Key InChIKey=OTKUTGIVEREJLL-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50028600   

LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataIC50: 2.03E+3nMAssay Description:Tested in vitro for its ability to displace 3[H] clozapine from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataIC50: 27nMAssay Description:Displacement of 3[H]spiroperidol from Dopamine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  0.540nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  0.540nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  2.5nMAssay Description:Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  2.5nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  3nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028600(1-(8-Chloro-dibenzo[b,f]oxepin-10-yl)-4-methyl-pip...)
Affinity DataKi:  84nMAssay Description:Affinity was evaluated by inhibition of [3H]GR-65630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed