BDBM50028599 1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine::CHEMBL275696

SMILES CN1CCN(CC1)C1=Cc2cc(Cl)ccc2Cc2ccccc12

InChI Key InChIKey=VYHUCPCVCHMNCC-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50028599   

LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataIC50: 342nMAssay Description:Displacement of 3[H]spiroperidol from Dopamine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataIC50: 670nMAssay Description:Tested in vitro for its ability to displace 3[H] clozapine from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataIC50: 670nMAssay Description:Concentration required (in vitro) to displace 50% specific binding of [3H]clozapine to Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataIC50: 342nMAssay Description:Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nucleiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  3nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  7nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  120nMAssay Description:Affinity was evaluated by inhibition of [3H]GR-65630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  520nMAssay Description:Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  520nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028599(1-(2-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  2.90E+3nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed