BDBM50026821 CHEMBL3331521::US11419874, Example 10::US9669035, B-1b

SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12

InChI Key InChIKey=JJQZDOKXARNTKH-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50026821   

LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE1A by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 4.18E+3nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 10nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 4.10E+3nMpH: 7.8 T: 2°CAssay Description:Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 7.40nMpH: 7.8 T: 2°CAssay Description:Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 4.80E+3nMpH: 7.8 T: 2°CAssay Description:Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 13nMpH: 7.8 T: 2°CAssay Description:Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Oslo University Hospital

US Patent
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE3B by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE7A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE9A1 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of human PDE11A4 expressed in Sf9 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50026821(US9669035, B-1b | CHEMBL3331521 | US11419874, Exam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed