BDBM50023727 CHEMBL3330170

SMILES FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1

InChI Key InChIKey=XUKGFHHTSUKORV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50023727   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Nas of Ukraine

Curated by ChEMBL
LigandPNGBDBM50023727(CHEMBL3330170)
Affinity DataIC50: 93nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Nas of Ukraine

Curated by ChEMBL
LigandPNGBDBM50023727(CHEMBL3330170)
Affinity DataIC50: 131nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Nas of Ukraine

Curated by ChEMBL
LigandPNGBDBM50023727(CHEMBL3330170)
Affinity DataIC50: 13nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Nas of Ukraine

Curated by ChEMBL
LigandPNGBDBM50023727(CHEMBL3330170)
Affinity DataIC50: 90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed