BDBM50022184 7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3)::7,8-Dihydroxy-4-methyl-chromen-2-one::7,8-dihydroxy-4-methyl-2H-chromen-2-one::7,8-dihydroxy-4-methylcoumarin::CHEMBL276618

SMILES Cc1cc(=O)oc2c(O)c(O)ccc12

InChI Key InChIKey=NWQBYMPNIJXFNQ-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50022184   

LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetProbable maltase-glucoamylase 2(Human)
Goa University

Curated by ChEMBL
LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) incubated for 20 mins before pNPG substrate addition and measured after 30 mins by UV spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataIC50: 1.12E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
S.G.S.I.T.S.

LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataKi:  270nM ΔG°:  -8.32kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataKi:  2.11E+3nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
S.G.S.I.T.S.

LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataKi:  6.60E+3nM ΔG°:  -6.56kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
S.G.S.I.T.S.

LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataKi:  8.70E+3nM ΔG°:  -6.41kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
S.G.S.I.T.S.

LigandPNGBDBM50022184(7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-Dihy...)
Affinity DataKi: >2.00E+5nM ΔG°: >-4.69kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped-flow instrument has been used for assaying the CA catalyzed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2017
Entry Details Article
PubMed