BDBM50021618 CHEMBL3297762::US9145418, 2

SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1

InChI Key InChIKey=UKZRGBUTBINTPD-UHFFFAOYSA-N

Data  59 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 50021618   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKC-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Syk (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 30nMAssay Description:Inhibition of human PIM1 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Bcr-ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NIM1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BUB1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDC7/DBF4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEukaryotic elongation factor 2 kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EEF2K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 37nMpH: 7.5Assay Description:Method for PIM2 Kinase Inhibition Assay: Dowex Technique i. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 73nMAssay Description:Inhibition of human PIM2 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PIM3 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of haspin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHigh affinity immunoglobulin gamma Fc receptor I(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1nMpH: 3.0Assay Description:Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P gamma ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021618(CHEMBL3297762 | US9145418, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
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