BDBM50021246 3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-1-yl)-N-methylpropan-1-amine::CHEMBL299233::[3-(3,3-Dimethyl-1-phenyl-1,3-dihydro-isobenzofuran-1-yl)-propyl]-methyl-amine(Talopram)

SMILES CNCCCC1(OC(C)(C)c2ccccc12)c1ccccc1

InChI Key InChIKey=LJBBMCNHIUJBDU-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50021246   

LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi:  795nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed