BDBM50020912 Largazole Thiol

SMILES [H][C@]1(CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@H](C(C)C)C(=O)O1)\C=C\CCS

InChI Key InChIKey=VEDPEVJAYWVUSJ-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50020912   

TargetHistone deacetylase 3(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 102nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 35nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 102nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed