BDBM50020890 CHEMBL3287250::US9216962, CFH382

SMILES CC(C)Cc1sc(nc1C(=O)NCCCCC(=O)NO)-c1nccs1

InChI Key InChIKey=BFMAQRHQZHOUNR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50020890   

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 47nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 102nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 1.22E+3nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 145nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC1 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 175nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC3 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 185nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC4 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shanghai Puyi Chemical

US Patent
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50: 123nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed