BDBM50020165 CHEMBL3288526::US9914707, I-4

SMILES Nc1ncnc2scc(-c3ccc4c(cccc4c3)C(=O)Nc3ccccc3)c12

InChI Key InChIKey=BYSPSKYBWHPEJW-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50020165   

TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant PDGFR-beta (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant RET (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant VEGFR-1 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 549nMAssay Description:Inhibition of recombinant PDGFR-alpha (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 644nMAssay Description:Inhibition of FGFR-1 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Flt-3 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR kinase domain (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ErbB2 expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ErbB4 using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant c-Src (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Abl (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant EPH-A2 (unknown origin) using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF-1R (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020165(CHEMBL3288526 | US9914707, I-4)
Affinity DataIC50: 1.5nMAssay Description:The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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