BDBM50018830 CHEMBL3286830::US10543199, Compound PF-06463922::US10780082, Compound PF-06463922::US11517561, Compound PF-06463922
SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
InChI Key InChIKey=IIXWYSCJSQVBQM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 82 hits for monomerid = 50018830
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS/Sodium-dependent phosphate transport protein 2B(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of SLC34A2-ROS1 (unknown origin) expressed in human HCC78 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
TargetHLA class II histocompatibility antigen gamma chain/Proto-oncogene tyrosine-protein kinase ROS(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibition of CD74-ROS1 (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human EML4-fused ALK L1152R mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of NRTK3 (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Taibah University
Curated by ChEMBL
Taibah University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild type EML4/ALK G1269A mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of PTK2 (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of TNK2 (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of PTK2B (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of FES (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of FER (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human EML4-fused ALK 1151Tins mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of human EML4-fused ALK G1202R mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of NRTK1 (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair