BDBM500185 US11021467, Compound 42

SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCN

InChI Key InChIKey=YXEXLSYLPLWISV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 500185   

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM500185(US11021467, Compound 42)
Affinity DataIC50: 15nMAssay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500185(US11021467, Compound 42)
Affinity DataIC50: 2nMAssay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500185(US11021467, Compound 42)
Affinity DataIC50: 1.40E+3nMAssay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent