BDBM50017666 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane::2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine::3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine::3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine::3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine::BROMPHENIRAMINE::CHEMBL811

SMILES CN(C)CCC(c1ccc(Br)cc1)c1ccccn1

InChI Key InChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N

Data  4 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50017666   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 891nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataKi:  6.06nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
LigandPNGBDBM50017666(2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyri...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed