BDBM50015677 (S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester::1,2-Dioctanoyl glycerol::1,2-dioctanoyl-sn-glycerol::CHEMBL55267::Octanoic acid 1-hydroxymethyl-2-octanoyloxy-ethyl ester::Octanoic acid 1-hydroxymethyl-2-octanoyloxy-ethyl ester(diC8)

SMILES CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC

InChI Key InChIKey=ZQBULZYTDGUSSK-UHFFFAOYSA-N

Data  9 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50015677   

TargetProtein kinase C delta type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataEC50:  1.62E+4nMAssay Description:Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataEC50:  8.19E+3nMAssay Description:Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataEC50:  5.24E+3nMAssay Description:Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenchingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  6.80nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetProtein kinase C eta type(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]- PDBu binding to peptide D of mouse skin Protein kinase C etaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  33nMAssay Description:Displacement of [20-3H] phorbol 12,13-dibutyrate from protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Bovine)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  33nMAssay Description:Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]PDBu from human recombinant PKCalpha expressed in Sf9 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  2.82E+3nM ΔG°:  -7.39kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  2.93E+3nMAssay Description:Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  6.70E+3nM ΔG°:  -6.89kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK beta(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM50015677(CHEMBL55267 | 1,2-dioctanoyl-sn-glycerol | 1,2-Dio...)
Affinity DataKi:  6.96E+3nM ΔG°:  -6.87kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed