BDBM50015089 2,N-Dihydroxy-benzamide::CHEMBL309339::N,2-dihydroxybenzamide::SALICYLHYDROXAMIC ACID::Salicylhydroxamic acid (SHA)::Salicylic hydroxamic acid::US11565996, Compound Salicylhydroxamic acid (SHAM)

SMILES c1ccc(c(c1)C(=O)NO)O

InChI Key InChIKey=HBROZNQEVUILML-UHFFFAOYSA-N

Data  8 IC50  1 Kd

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50015089   

TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 2.50E+4nMpH: 6.5Assay Description:Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2017
Entry Details Article
PubMed
TargetThyroid peroxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 2.00E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2017
Entry Details Article
PubMed
TargetLactoperoxidase(Bovine)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 400nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to recombinant human myeloperoxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMyeloperoxidase(Human)
University of Otago Christchurch

LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human myeloperoxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 3.02E+4nMAssay Description:Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlternative oxidase, mitochondrial(Trypanosoma brucei brucei)
Instituto De Qu£Mica M£Dica

Curated by ChEMBL
LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 5.93E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei brucei alternative oxidase using ubiquinol-1 as substrate incubated for 2 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUbiquinol oxidase 1, mitochondrial(Voodoo lily)
Alternox Scientific

US Patent
LigandPNGBDBM50015089(Salicylic hydroxamic acid | SALICYLHYDROXAMIC ACID...)
Affinity DataIC50: 7.00E+3nMAssay Description:Table 1 summarises the concentration of inhibitor required to reduce the respiration of purified recombinant AOX protein by 50%. Respiration was meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent