BDBM50014647 1,2-Dimethyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol; hydrobromide::CHEMBL544714

SMILES CN1CCc2cc(O)c(O)cc2C1

InChI Key InChIKey=WETXYFNVBDLWIW-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50014647   

TargetNeuronal acetylcholine receptor subunit beta-2(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50: 1.00E+6nMAssay Description:Antagonist activity at rat alpha3/beta4 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane pot...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  6.80E+3nMAssay Description:Displacement of [3H]epibatidine from rat alpha4/beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4/beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha3/beta4 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50014647(CHEMBL544714 | 1,2-Dimethyl-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  1.30E+6nMAssay Description:Compound was tested for inhibition against human placental Monoamine oxidase A (competitive inhibition was observed)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed