BDBM50014132 CHEMBL2323032

SMILES On1ncc2cc(CCc3nn[nH]n3)ccc12

InChI Key InChIKey=YGDLGRHJAGOPII-UHFFFAOYSA-N

Data  7 KI  4 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50014132   

TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein-labeled human E-cadherin (residues 819-873) interaction by FP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein-labeled human APC-R3 (residues 1477-1519) interaction by FP co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKd:  530nMAssay Description:Binding affinity to beta catenin ARD (142 to 686 residues) (unknown origin) assessed as dissociation constant by VP-ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKd:  530nMAssay Description:Binding affinity to human beta-catenin (138 to 686 residues) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKd:  531nMAssay Description:Displacement of biotinylated TCF4 from wild type beta-Catenin (unknown origin) assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataIC50: 500nMAssay Description:Inhibition of beta catenin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to beta catenin ARD (142 to 686 residues) (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetTranscription factor 7-like 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human beta-casein/Tcf4 interaction after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.14E+3nMAssay Description:Competitive binding affinity to human beta-catenin (142 to 686) assessed as inhibition of C-terminally fluorescein-labeled Tcf4 interaction after 3 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTranscription factor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.14E+3nMAssay Description:Inhibition of wild type beta-Catenin (142 to 686 residues) (unknown origin)/C-terminal fluorescein-labeled human TCF4 (7 to 51 residues) protein-prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCatenin beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetTranscription factor 7-like 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of human beta-casein/Tcf4 interaction after 1 hr by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed