BDBM50013822 CHEMBL3265276::US10323013, Compound 36

SMILES CC(=O)c1c(O)ccc2c3CCN(Cc3c(=O)oc12)C(=O)OCC=C

InChI Key InChIKey=NPQCSLDFJZDGTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50013822   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50013822(CHEMBL3265276 | US10323013, Compound 36)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50013822(CHEMBL3265276 | US10323013, Compound 36)
Affinity DataIC50: 2.00E+4nMAssay Description:All compounds were evaluated by FRET-suppression assay in side-by-side experiments using 21b as a control inhibitor (Table 2). Protection of the alde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent