BDBM50013091 2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-one::CHEMBL51613

SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl

InChI Key InChIKey=RZBANNTZMKJFNR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50013091   

TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2019
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase (TK) assay for herpes simplex virus type 2 (HSV-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase (TK) assay for herpes simplex virus type 1 (HSV-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA primase(HHV-1)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA primase(HHV-1)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 880nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]dTTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase(HHV-2)
University of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(CHEMBL51613 | 2-(3,4-Dichloro-phenylamino)-1,9-dih...)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2019
Entry Details Article
PubMed